منابع مشابه
Precision medicine becomes reality—tumor type-agnostic therapy
Precision medicine just witnessed two breakthroughs in oncology in 2017. Pembrolizumab (Keytruda), Merck’s antiprogrammed cell death-1 (PD-1) monoclonal antibody (mAb), received accelerated approval in May 2017 by the US Food and Drug Administration for the treatment of adult and pediatric patients with unresectable or metastatic solid tumors that have been identified as having microsatellite i...
متن کاملTherapy that gets inside your head--literally.
BY JOHN SIMONS Robert Fischell z r quadriplegics move motorized apsays lnventlng thlngs is a two-stage pendages. Health-care equipment process. "Slage one: Everyone says it's makers such as Johnson 8r Johnson impossstble," he explains. "Stage two: and M e d t m c are invesllng heady in They say the sniution was obvious all bran stimutatiun tou. along." Fischell would km-he's the Seven years ago...
متن کاملOn Trk for Retrograde Signaling
Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk receptors then stimulate local effects at nerve terminals, and retrograde effects at neuronal cell bodies that often reside at considerable distances from the terminals. However, the nature of the retrograde signal h...
متن کاملMimotope vaccine efficacy gets a "boost" from native tumor antigens
Tumor-associated antigen (TAA)-targeting mimotope peptides exert more prominent immunostimulatory functions than unmodified TAAs, with the caveat that some T-cell clones exhibit a relatively low affinity for TAAs. Combining mimotope-based vaccines with native TAAs in a prime-boost setting significantly improves antitumor immunity.
متن کاملAgnostic Clustering
Motivated by the principle of agnostic learning, we present an extension of the model introduced by Balcan, Blum, and Gupta [3] on computing low-error clusterings. The extended model uses a weaker assumption on the target clustering, which captures data clustering in presence of outliers or ill-behaved data points. Unlike the original target clustering property, with our new property it may no ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2018
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.360.6384.45-d